High Desert Health, LLC
Tributyrin-Max
Tributyrin-Max
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Postbiotic Colon and Microbiome Support*
60 capsules • 750 mg tributyrin per capsule (one of the highest-dose available)
Enteric-coated, 3rd-party tested gluten and dairy-free
Free shipping on 1-3 bottles.
HOW TRIBUTYRIN-MAX SUPPORTS GUT HEALTH
How it works: Tributyrin is a slow-release form of butyrate, a beneficial postbiotic that supports the cells lining the colon, gut barrier integrity, microbiome balance and healthy inflammatory signaling*
Who it’s for: People with loose stools, fast digestive transit, bloating or gut disruption during and after antibiotics*
What it supports: Stool consistency and healthy digestive transit through increased butyrate availability*
Symptom support: Helps reduce bloating, digestive discomfort and visceral sensitivity (digestive pain signals)*
Immune support: Supports a balanced immune response in the gut*
What to expect: Stool changes may be noticed within days, with deeper gut barrier and microbiome effects over 4–6 weeks
Targeted delivery: Enteric-coated capsules protect tributyrin from stomach acid and release it in the intestines, where butyrate is most needed*
HOW BUTYRATE SUPPORTS DIGESTIVE FUNCTION
Butyrate plays a central role in digestive health by supporting intestinal motility, gut lining integrity and the balance of the gut microbiome. When food moves too quickly through the digestive tract, less water is absorbed, often leading to loose stools and bloating. By supporting healthy motility and the cells lining the colon, butyrate helps create conditions that favor firmer stools and digestive comfort.*
Butyrate is also a primary fuel source for colonocytes, the cells that line the colon. When these cells are adequately nourished, they help maintain a strong gut barrier and a low-oxygen (anaerobic) environment that supports beneficial bacteria while discouraging inflammatory microbes.*
RESEARCH-SUPPORTED EFFECTS OF BUTYRATE IN THE GUT
Peer-reviewed research has shown that butyrate supports multiple aspects of gastrointestinal function, including slowing intestinal transit to allow greater water absorption, supporting gut barrier integrity, moderating visceral sensitivity (digestive pain signaling) and balanced inflammatory responses in the gut.*
By supporting a low-oxygen environment in the colon, butyrate also helps maintain a microbiome balance that favors butyrate-producing anaerobic bacteria. This environment may be disrupted during and after antibiotic use, when natural butyrate production is often reduced.*
BENEFITS BEYOND THE DIGESTIVE TRACT
In addition to its role in digestive health, research suggests that butyrate supports balanced immune signaling and healthy metabolic function, including energy regulation and glucose metabolism.*
WHY TRIBUTYRIN INSTEAD OF OTHER FORMS OF BUTYRATE
Tributyrin is a molecular form of butyrate in which three butyrate molecules are bound to glycerol. This structure gives tributyrin distinct properties, including improved delivery and tolerability.*
Unlike mineral forms of butyrate (such as sodium, calcium or magnesium butyrate), tributyrin has low odor, greater chemical stability and releases butyrate gradually within cells rather than being rapidly metabolized at the intestinal surface by colonocytes. This slow-release delivery allows for more sustained butyrate availability where it is needed most.*
WHAT IS BUTYRATE?
Butyrate is a short-chain fatty acid naturally produced when beneficial gut bacteria ferment dietary fiber. It provides energy for the cells lining the colon and plays a key role in maintaining gut barrier integrity and microbiome balance. Colonocyte metabolism of butyrate consumes a significant amount of oxygen, helping maintain an anaerobic environment that supports beneficial bacteria.*
Research has shown that disruptions to this system, such as antibiotic exposure, can reduce butyrate production and increase oxygen levels in the gut, creating conditions that favor inflammatory bacteria and digestive imbalance. Supplemental butyrate may help support restoration of a healthier gut environment.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Certificate of Analysis for Tributyrin-Max expiration date 6/27
1. Canani, RB et al. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011 Mar 28; 17(12): 1519–1528. doi:10.3748/wjg.v17.i12.1519
2. Siddiqui MT, Cresci GAM. The Immunomodulatory Functions of Butyrate. J Inflamm Res. 2021;14: 6025–6041. doi:10.2147/JIR.S300989
3. Kelly CJ et al. Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. Cell Host Microbe. 2015;17: 662–671. doi: 10.1016/j.chom.2015.03.005
4. Takahashi, D et al. Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine. 2020; 58: 102913. doi:10.1016/j.ebiom.2020.102913
5. Arora T & Tremaroli V. Therapeutic Potential of Butyrate for Treatment of Type 2 Diabetes. Front Endocrinol. 2021;12: 761834. doi: 10.3389/fendo.2021.761834
6. Coppola S, Avagliano C, Calignano A, Berni Canani R. The Protective Role of Butyrate against Obesity and Obesity-Related Diseases. Molecules. 2021;26. doi: 10.3390/molecules26030682
7. Mailing, L. (2019). The Oxygen Gut Dysbiosis Connection. https://www.lucymailing.com/the-oxygen-gut-dysbiosis-connection/
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Let customers speak for us
from 24 reviewsThis stuff is AMAZING. Especially if you have trouble assimilating food. You WILL assimilate THIS, and it will show (on your face) in a positive way. I can feel it, and I can see it. trick is to learn how to TAKE it... (get a round 1/4 tea spoon and drop it onto your tongue WHILE HOLDING a little WATER IN YOUR MOUTH. keep it on your tongue, and not on your teeth (swallow it without allowing it to touch your teeth... It takes a little time to get the technique, but eventually you will be able to pound 3 or 4 spoonfuls pretty quickly using this method.
Great stuff. I am so regular now it's amazing. And I feel very healthy. I think it's a worthwhile and even essential supplement.
For those of us who suffer with Postcholysysectomy Syndrome after Gallbladder removal, this product is very helpful. I have dealt with PCS for years and I have tried everything for gut issues. I take one capsule with each meal. It helps to firm stools. A great product I can’t live without!
I was on the fence because usually when a trademarked, scripted medical food (Enteragam) becomes an OTC supplement (Immunolin) it's because clinical efficacy just isn't strong enough to keep it a prescription. Pharma = $. You know the drill. Unfortunately, I had the opposite reaction where inflammation increased in my gut and loose stools increased even with lowering to just a 1/4 dose. I really gave this a 4-week trial and when I stopped my gut went "back to normal" so trying it seems safe. It did seem that IgG binds "something" so that can be beneficial with selected use protocols in the right individuals. I was hopeful this would calm my gut but maybe I simply don't need more IgG in my gut and adding it caused issue in ME, maybe not YOU. My immune system did seem "boosted" so I can see benefit there if warranted. Keep in mind, this is a slaughter house bi-product. Not that that is a bad thing; Proliant's manufacturing purity of this product is intact with but knowing the source of what goes in your body is important. I will keep it on hand for acute situations.
Great product
After suffering from some potentially devastating GI conditions, this product has helped me turn the corner in my journey back towards health.
Great service, great communication. Tributyrin Max has not been as helpful as expected. Seems that 1 cap a day is better than taking 3 a day. (Have IBSd.) Looking forward to video meeting for better understanding.
The Tributyrin-Max added the extra support with an going struggle. It did what it said it would do. Really appreciate that.
Um… no. This appeared to work the first day I took it but has not worked any time thereafter. I’m back to regular fiber supplements and had to take MORE fiber supplements with this constipating product. Pass (pardon the pun).
My son is 7 and takes this every day!! It’s such a great product!!! Won’t ever go without it!
Lindsey first put me on this when I had some oily stools. I realized it was associated with dairy intolerance, and even when I wasn’t consuming dairy I had this issue with my stool, generally leaky gut symptoms. This helped drastically. Fixed it pretty quick, and I haven’t had that problem in a long time.
I was having so many stomach / bowel issues. Helped to coat my stomach and stop pouring diarrhea. I'm pleasantly surprised by the fast results and overall improvement I've had on this product. Now, my husband is trying it for acid reflux. I'm so happy to have found this product and the podcast to talked about it. Amazing really!
This is a great product. I have tried other Butyrate brands to no avail and read about the absorbency of this product so I figured I would give it a try. In days I had major improvement. I take 2 daily at 2 different meals. I also added a liquid B1 which helps. Butyrate is a key to improving digestion and making it absorbable is key particularly when people may not be absorbing vitamins efficiently.
At this time have not taken it. I am in the process of trying various ones. I know the Tributyrin works, because Dr. Gundry's original formula which had a 1000 gr worked, but he change his formula to 300 and that is not working for me. I had bought various bottles of his product. I am taking 3 pills of Dr. Gundry to equal 450 gr plus another supplier that had over 500 gr to equal my 1000. Five days on that changed my issue. So very frustrated the formulas were changed. No updated info on why? So the search was on and also concern with not obeying the bottle recommendations.
Like: Compared another brand of Butyrate — lower: dose (500 mg) and price — but with inconsistent resultsDislike: Expensive